I have the 70-300 DO because at the time of purchase the alternative was the less than stellar 75-300. The DO is a lovely lens but quite heavy though well balanced and I love it but given the same decision today would look long and hard at the present none DO and probably go with that, especially for a one off trip. As Clive says you may be able to afford the 100 L IS macro then and that would decide it for me.
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