Grain/noise can be reduced using programs such as neatimage. If shooting RAW images a RAW converter can also reduce noise. The larger filesizes of both D80 and D200 may permit more aggressive cropping which can be useful, particularly with wildlife photography. D50 employs in-camera noise reduction and is aimed at a different market sector to your D100. It therefore should be possible to produce the same smooth image as D50 from a D80/200 by employing post processing noise reduction.
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