I too have the 70-300 DO IS USM. Love it and on your 350d gives 480 equivalent focal length. The main criticisms you will come across on various forums are a tendency to flare when shooting with a bright light source just out of the image, and sometimes odd artifacts around very bright highlights caused by the DO part of the optical train. Never had either of these problems myself (I always use the supplied hood). Another lens to consider is the latest version of the none DO 70-300 IS lens which is much cheaper and is optically very good. Make sure if you buy one (none DO) that you get the very latest version as the early ones had problems with their mechanical design and construction since corrected. Love my DO and it is my walk about lens and gets used more than any of my other lenses.
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