I get some approximately similar results, Leif. I read up on profiles a bit when I got my Spyder a few months back. As you know, it's an arcane and complicated area. Going on my vague memories, what is happening has to do with the fact that there are two profiles at work when you look at any image:
* the image's own profile (call this the "input profile" because I forget the proper term)
* the profile of the output device (e.g., the monitor profile).
Most (but not all) graphics programs don't use profiles at all. However, if you are using a graphics card that understands profiles, and you have calibrated your monitor with the Spyder utility (or another similar one), then every program that uses the graphics card - i.e., all of them - should be outputting images using the monitor profile.
But most programs don't understand the input profile that is attached to the image by Photoshop (and certain other graphics apps). Firefox and the Windows Image Viewer are, if I've got this right, ignoring the input profile.
But what's going on when you re-open the image in PS, I have no idea!
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