A simple graphic composition will work in all formats, but really as a work of design rather than detail. (The 'less is more' philosophy of landscape composition for example) Detailed images work best as 'in the hand' formats - cards or small-medium prints (eg up to A4), or as jigsaws!
For a thumbnail, either very strong composition or a striking subject larg ein the frame are needed - there is not enough space for subtlety.
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