A friend of mine recently made a similar change (went from a Sigma 170-500 to a 100-400 IS) and is very pleased that she did. She has found that although she sometimes misses the extra reach the IS means she gets far more keepers when the bird is in range of the 400mm. I have no experience of the Nikon 80-400 VR but if it's in the same league as the Canon 100-400 IS then I think it would be worth it.
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