All the systems have pros and cons - as I never buy things like flashes and stick to a couple of lenses [bought s/hand to avoid depreciation], I've never had any qualms about switching systems. Canon to Nikon/Fuji to Canon/Olympus to Olympus to Canon. Lens availabity can be a big incentive. If you're spending most of your money on a long lens then the 28-135mm IS is a pretty nice walkaround lens at a reasonable price - picked mine up for about 200.00.
I've always preferred Nikon to Canon but have to say the 40D is extremely good!
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