All depends on the type of photography that you specialise in. I believe that DX cropped sensors would be advantageous for the wildlife and aviation photographer. However wedding and portraiture styles would benefit from full frame FX sensors due to better wide angle performance and low light characteristics.
Personally as I specilise in aviation photography I would have to get close to the subject as for safety reason I cannot do that. FX is the only option for me.
Technically there would be more vignetting on a full frame FX sensor and the DX benefits from any lens central sweet spot.
Horses for courses!
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