That does sound very strange indeed - I have both of those cameras too and have used all three of those lenses and found that they all gave good results on any body (I have never had a body/lens calibratted and never used microadjust). The 50mm is a bit soft wide open but sharpens up by about f2.2, the other two should be plenty sharp enough wide open but will sharpen up a bit a you stop down. My first thought is to check if you have filters on the lenses. Opinion as to whether a filter for protection is a good idea varies widely but it is very easy to prove that a filter does degrade the image quality. If you do have filters fitted they could account for the problem, especially if they are cheaper ones. Also don't be scared to push the ISO up to allow for faster shutter speeds (help avoid shake and motion blur), both your cameras are very good at high ISO especially the 5D.
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