I shoot mostly outdoors under natural light, and must admit I tend to leave it in 'auto'. But, I shoot RAW only and so it is an easy job to correct any colour casts in post-processing.
If you are shooting under particular lighting conditions, for example deep shade, tungsten lighting, fluorescent light, you will get a colour cast because of the light's colour temperature. Setting the appropriate white balance for the lighting should minimise this, but as I say, if shooting RAW it is easily changed anyway. Only a major issue for jpegs straight from the camera would be my feeling...
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