While I don't use Neat Image, I use Noiseware Professional, I do almost always apply noise reduction before I do any other work on the image. I may sometimes just use a slight amount of brightness control if necessary to lighten the image before I apply noise reduction. The last thing I do is run unsharp mask to add the required amount of sharpening to the finished image before saving it to file with a unique title.
nirofo.
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