I doubt that you will see a difference a quick test shows that after conversion from a 16.5mb Tiff to 1.4 mb Jpg, then back to Tiff, the file size is again 16.5mb.
Even if you save the 16.5mb as Jpg with 50% compression (263Kb), the conversion back to 16 bit is again 16.5mb.
Given all the above I feel that something as been lost, so all my files are saved as Tiffs.
Harry
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