I've not seen any problems, I had one email offering an upgrade to a more advanced version of one of the programs, and as sassan says the comments from other dowloaders aren't talking about spyware etc. There were some reports of McAffee reporting false positives in one program some months ago, none of the other spyware, or anti-virus programs found a problem, and it was put down to stupid McAfee again.
Also as sassan says just be selective with what you have run at startup.
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